Which drug is primarily used for its analgesic effects and is a reversible COX inhibitor?

Explore the USMLE Step 3 Drug MOA Test. Use flashcards and multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Acetaminophen is primarily known for its analgesic (pain-relieving) and antipyretic (fever-reducing) effects. It functions mainly as a reversible inhibitor of cyclooxygenase (COX), though its exact mechanism is not entirely understood. Acetaminophen is thought to inhibit COX enzymes in the central nervous system, which leads to a decrease in the synthesis of prostaglandins, compounds that mediate pain and inflammation. This action makes it effective for alleviating mild to moderate pain and reducing fever.

The other options listed do not serve primarily as analgesics or do not act through COX inhibition. Finasteride is used for its effect on dihydrotestosterone and treats conditions like benign prostatic hyperplasia and male pattern baldness rather than serving as a pain reliever. IL-2 is an immunomodulatory agent used in cancer treatments and is not related to pain relief. Valproic acid is an anticonvulsant and mood-stabilizing drug, not primarily utilized for analgesia or COX inhibition. Thus, acetaminophen stands out as the correct choice due to its role in pain management and reversible COX inhibition.

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