USMLE Step 3 Drug MOA Practice Test

Image Description

Question: 1 / 400

What is the primary result of aspirin's action on cyclooxygenase (COX)?

Increased thromboxane A2 production

Decreased formation of inflammatory mediators

Aspirin primarily exerts its effects by irreversibly inhibiting cyclooxygenase (COX), which is crucial in the conversion of arachidonic acid into prostaglandins and thromboxanes. The inhibition of COX leads to decreased formation of inflammatory mediators, including prostaglandins that are responsible for mediating inflammation, pain, and fever. Furthermore, the reduction in thromboxane A2 synthesis—specifically in platelets—results in diminished platelet aggregation, contributing to aspirin's effectiveness as an antiplatelet agent. Thus, option B accurately reflects the primary result of aspirin's mechanism of action on COX, highlighting its role in reducing inflammatory processes.

Get further explanation with Examzify DeepDiveBeta

Inhibition of leukotriene synthesis

Enhanced platelet aggregation

Next Question

Report this question

Download USMLE Step 3 Drug MOA Practice Test PDF Study Guide
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy