What therapeutic use does colchicine primarily have?

Colchicine is primarily used for the treatment of gout, which is a form of inflammatory arthritis characterized by sudden and severe pain, redness, and swelling in the joints, often affecting the big toe. The therapeutic mechanism of colchicine involves its impact on neutrophil migration and activation, which are crucial steps in the inflammatory response associated with gout flares. By disrupting microtubule formation, colchicine inhibits the movement of these neutrophils to sites of inflammation, thus reducing the inflammatory reaction and alleviating symptoms of an acute gout attack.

Additionally, colchicine can be used for chronic management in gout, helping to prevent future flare-ups by inhibiting the inflammatory response to uric acid crystals. Its distinct mechanism of action and specific indication for gout make it an important medication for individuals suffering from this condition.