What is one of the actions of valproic acid?

Explore the USMLE Step 3 Drug MOA Test. Use flashcards and multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Valproic acid is primarily known for its role as an anticonvulsant and mood stabilizer. One of its key actions is enhancing GABA (gamma-aminobutyric acid) accumulation in the brain. This occurs through multiple mechanisms: it increases the activity of the enzyme that synthesizes GABA, enhances the release of GABA, and inhibits the enzymes that break it down. By increasing GABA levels and enhancing its inhibitory effects, valproic acid helps to stabilize neuronal excitability and reduce the frequency and severity of seizures.

The other options presented are associated with different drug actions and mechanisms of action. For example, inhibiting mycolic acid synthesis relates to the actions of certain antitubercular agents, while the inhibition of xanthine oxidase pertains to drugs used in the treatment of gout, such as allopurinol. Lastly, the actions described regarding agonists in bone and the uterus are linked to drugs that have effects on hormone receptors, such as some estrogen or progesterone analogs.

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