What effect do cholecystokinin analogs have on digestive function?

Explore the USMLE Step 3 Drug MOA Test. Use flashcards and multiple-choice questions, each with hints and explanations. Ace your exam with confidence!

Cholecystokinin (CCK) is a hormone that plays a significant role in digestion. It is released by the cells in the small intestine in response to the presence of fatty acids and amino acids. One of the key effects of CCK is to stimulate the exocrine pancreas to release digestive enzymes, which include proteases, lipases, and amylases. These enzymes are crucial for the breakdown of proteins, fats, and carbohydrates in the digestive tract, facilitating nutrient absorption.

In addition to stimulating enzyme secretion, CCK also promotes gallbladder contraction, leading to the release of stored bile, which is important for the emulsification and absorption of dietary fats. It does not inhibit gallbladder contraction, nor does it increase bile salt production directly. While CCK can have an appetite-suppressing effect, its primary and most significant role in the digestive process relates to stimulating the secretion of digestive enzymes. Therefore, the selection of the response highlighting the stimulation of enzyme secretion correctly emphasizes the essential role that CCK plays in enhancing digestive function.

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